SKF-96365 hydrochloride
CAS No. 130495-35-1
SKF-96365 hydrochloride ( —— )
Catalog No. M11222 CAS No. 130495-35-1
SKF-96365, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells.
Purity : >98%(HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 47 | In Stock |
|
10MG | 70 | In Stock |
|
25MG | 127 | In Stock |
|
50MG | 230 | In Stock |
|
100MG | 446 | In Stock |
|
200MG | 680 | In Stock |
|
500MG | 1053 | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSKF-96365 hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionSKF-96365, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells.
-
DescriptionSKF-96365, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 inhibited hERG current in a concentration-dependent manner.
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorTRP
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number130495-35-1
-
Formula Weight402.91
-
Molecular FormulaC22H27ClN2O3
-
Purity>98%(HPLC)
-
SolubilityWater: 100 mM
-
SMILESCOC1=CC=C(C=C1)CCCOC(CN2C=CN=C2)C3=CC=C(C=C3)OC.Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Singh A, et al. Br J Pharmacol. 2010, 160(6):1464-1475.
molnova catalog
related products
-
CIM0216
CIM0216 is a synthetic TRPM3 activator whose potency and apparent affinity greatly exceeds that of the canonical TRPM3 agonist.
-
Pyr3
Pyr3 is a selective transient receptor potential canonical channel 3 inhibitor. Pyr3 inhibits TRPC3-mediated Ca2+ influx in a dose-dependent manner(IC50 = 700 nM).
-
EIPA
EIPA (L593754, MH 12-43) is a TRPP3 channel inhibitor (IC50: 10.5 μM). It also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca2+-activated TRPP3 channel activation at -50 mV, with IC50s of 143, 10.5, 1.1, and 0.14 μM, respectively.