SKF-96365 hydrochloride

CAS No. 130495-35-1

SKF-96365 hydrochloride ( —— )

Catalog No. M11222 CAS No. 130495-35-1

SKF-96365, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 47 In Stock
10MG 70 In Stock
25MG 127 In Stock
50MG 230 In Stock
100MG 446 In Stock
200MG 680 In Stock
500MG 1053 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    SKF-96365 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    SKF-96365, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells.
  • Description
    SKF-96365, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 inhibited hERG current in a concentration-dependent manner.
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    130495-35-1
  • Formula Weight
    402.91
  • Molecular Formula
    C22H27ClN2O3
  • Purity
    >98%(HPLC)
  • Solubility
    Water: 100 mM
  • SMILES
    COC1=CC=C(C=C1)CCCOC(CN2C=CN=C2)C3=CC=C(C=C3)OC.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Singh A, et al. Br J Pharmacol. 2010, 160(6):1464-1475.
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