SKF-96365 hydrochloride
CAS No. 130495-35-1
SKF-96365 hydrochloride ( —— )
Catalog No. M11222 CAS No. 130495-35-1
SKF-96365, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells.
Purity : >98%(HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
5MG | 47 | In Stock |
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10MG | 70 | In Stock |
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25MG | 127 | In Stock |
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50MG | 230 | In Stock |
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100MG | 446 | In Stock |
|
200MG | 680 | In Stock |
|
500MG | 1053 | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameSKF-96365 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionSKF-96365, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells.
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DescriptionSKF-96365, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal Y cells. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibited the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade in vitro and in vivo. Overexpression of CaMKIIγ or AKT abolished the effects of SKF-96365 on Y cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects. SKF-96365 inhibited hERG current in a concentration-dependent manner.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRP
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number130495-35-1
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Formula Weight402.91
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Molecular FormulaC22H27ClN2O3
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Purity>98%(HPLC)
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SolubilityWater: 100 mM
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SMILESCOC1=CC=C(C=C1)CCCOC(CN2C=CN=C2)C3=CC=C(C=C3)OC.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Singh A, et al. Br J Pharmacol. 2010, 160(6):1464-1475.
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